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class="borderall" style="height:21px;"/> </form> </div> 鎮ㄧ幇鍦ㄧ殑浣嶇疆锛欬a href="/">棣栭〉</a> >> <a href="/Class.asp?ID=3">淇℃伅涓績</a> >> <a href="/Class.asp?ID=8">鏂拌嵂鐮斿彂</a> >> 鍐呭 </div> <div id="nw_left"> <div id="web2l"> <h1>姣忔湀鑽墿蹇 --2014骞?鏈圏/h1> <h3>鏃堕棿锛?014-7-30 11:25:54</h3> <div id="content"> TAKEDA 鍏徃鍦ㄦ棩鏈帹鍑 ZACRAS 鍜屾柊鍓傞噺 AZILVA Takeda Pharmaceutical 鍏徃瀹ｅ竷 Zacras(R) 鍜 Azilva(R) 鐜颁粖鍦ㄦ棩鏈潰甯傦紝鐢ㄤ簬娌荤枟楂樿鍘嬬梾锛屽墠鑰呮槸闃块綈娌欏潶/鑻：閰告皑姘湴骞冲浐瀹氬墏閲忓鏂圭墖鍓傦紝鍚庤€呮槸闃块綈娌欏潶 10 mg 鐗囧墏銆俍acras 姣忔棩涓€娆＄粡鍙ｆ湇鐢紝鎷ユ湁楂樺墏閲忥紙20 mg 闃块綈娌欏潶/ 5 mg 姘ㄦ隘鍦板钩锛夊拰浣庡墏閲忥紙20 mg 闃块綈娌欏潶 / 2.5 mg 姘ㄦ隘鍦板钩锛変袱绉嶈鏍笺€傚凡缁忓湪鍞殑 Azilva 鐗囧墏鏈 20 鍜 40 mg瑙勬牸锛?0 mg 鐗囧墏灞炰簬鏂扮殑鍓傞噺瑙勬牸锛圱akeda Pharmaceutical 鏂伴椈绋匡級銆 FDA 鎵瑰噯 LYMPHOSEEK 鐢ㄤ簬澶撮閮ㄧ檶鐥 FDA 鎵瑰噯浜 Navidea Biopharmaceuticals 鍏徃鎵╁ぇ浣跨敤 Lymphoseek(R) (閿漈c 99m tilmanocept) 娉ㄥ皠鍓傜殑閫傚簲鐥囷紝鐢ㄤ簬鎸囧鍙ｈ厰槌炵姸缁嗚優鐧屾偅鑰呭ご棰堥儴鐧岀棁鐨勫墠鍝ㄦ穻宸寸粨娲绘銆侺ymphoseek 鎴愪负棣栦釜涓 FDA 鍞竴鎵瑰噯鐨勭敤浜庢鏌ュ墠鍝ㄦ穻宸寸粨鐨勬斁灏勬€ц嵂鍝佺敵璇凤紝鍗冲皢涓婂競銆傛湰娆＄敵璇锋槸鎸夊揩閫熼€氶亾鍜屼紭鍏堣瘎瀹¤祫鏍兼壒鍑嗙殑銆侼avidea 鍏徃鐨 NEO3-06 鍓嶇灮鎬 III 鏈熺爺绌惰〃鏄庯紝涓庣幇琛岄噾鏍囧噯鐨勫绾ф穻宸寸粨娓呮壂鍜岀梾鐞嗘鏌ョ浉姣旓紝Lymphoseek 鑳芥纭瘑鍒梾鐞嗛槼鎬ф穻宸寸粨鎮ｈ€咃紝鍏锋湁缁熻瀛︽剰涔夛紝杩欎簺鏁版嵁鏀寔浜嗗叾鑾锋壒锛圕linicalTrials.gov 鏍囪瘑鍙 NCT00911326锛夈€傝繖浜涘彂鐜拌〃鏄 Lymphoseek 鍑嗙‘璇嗗埆鍑哄緟璇勪及璇曢獙鍙楄瘯鑰呬腑鐨勫墠鍝ㄦ穻宸寸粨锛屾垨璁歌兘棰勬祴娣嬪反缁撴€讳綋鐥呯悊鐘跺喌銆傛澶栵紝璇曢獙涓鍙楄瘯鑰呯殑鐧岀棁闃虫€ф穻宸寸粨瀹炴柦澶氱骇娓呮壂锛屼娇寰楁瘡渚嬫偅鑰呭钩鍧囧垏闄 38 涓穻宸寸粨锛岃€ Lymphoseek 骞冲潎鍒囬櫎 4 涓穻宸寸粨锛屽ぇ澶ч檷浣庝簡琛屽墠鍝ㄦ穻宸寸粨娲绘鐨勫ご棰堥儴鐧岀棁鎮ｈ€呯殑娼滃湪骞跺彂鐥囩巼銆侺ymphoseek 鍘诲勾棣栨鑾锋壒鐢ㄤ簬涔宠吅鐧屽拰榛戣壊绱犵槫鎮ｈ€呯殑娣嬪反缁樺浘銆侼avidea 鍏徃杩樻湁涓€浠 sNDA 姝ｅ湪 FDA 璇勫锛屽皢杩涗竴姝ユ墿灞 Lymphoseek 鐨勮鏄庝功锛岄噸鐐规槸鏇翠负鐏垫椿鍜屾洿涓洪暱鏈熺殑浣跨敤瑙勮寖銆侳DA 缁欏叾鎸囧畾鐨勭敓鏁堟棩鏄 2014 骞 10 鏈 16 鏃ワ紙Navidea Biopharmaceuticals 鏂伴椈绋匡級銆浼樺寲 GPR40 婵€鍔ㄥ墏娌荤枟 2 鍨嬬硸灏跨梾 Amgen Inc 鍏徃鐨勭瀛﹀浠彂琛ㄤ簡涓€绡囪鏂囷紝浠嬬粛浜嗗鑻熀涓欓吀琛嶇敓 G 铔嬬櫧鍋惰仈鍙椾綋 40 婵€鍔ㄥ墏 AMG 837 杩涜浼樺寲锛屽埗澶囧嚭娌荤枟 2 鍨嬬硸灏跨梾鐨勬柊鍨嬩复搴婂€欓€夎嵂锛屽鍙皢浠讳綍涓灑绁炵粡绯荤粺涓嶈壇浣滅敤闄嶅埌鏈€浣庣殑 AM-4668銆備互鍓嶆姤閬撹繃 AMG 837 鏄 G-铔嬬櫧鍋惰仈鍙椾綋 40 (GPR40) 鐨勫己鏁堥€夋嫨鎬ф縺鍔ㄥ墏锛岃閫変负娌荤枟 2 鍨嬬硸灏跨梾锛圱2DM锛夌殑涓村簥鍊欓€夎嵂銆侴PR40 鍦ㄥぇ鑴戝唴琛ㄨ揪锛屼絾瀵瑰叾鍔熻兘浜嗚В寰椾笉澶氥€傛不鐤 T2DM 鏃讹紝鍦ㄨ儼鑵尾缁嗚優涓彂鐜颁簡鐩爣 GPR40銆傚洜姝わ紝鐮旂┒浜哄憳閫氳繃寮曞叆鏇村ぇ鐨勬瀬鎬ц〃闈紝瀵瑰叾杩涜浼樺寲锛岄檷浣庡ぇ鑴戠┛閫忔€э紝鍙戠幇浜嗕笉绌块€忓ぇ鑴戠殑 GPR40 婵€鍔ㄥ墏 AM-4468锛堝寲鍚堢墿 10锛夈€侫M-4468 灞炰簬涓€绉嶅紓鍣佸攽锛屼笌鍏舵瘝浣撳寲鍚堢墿锛圗D50: 41-104 nM锛夌浉姣旓紝娲讳綋澶栬緝浣庣撼鎽╁皵娴撳害锛圗D50: 3.6-36 nM锛変究鏄洿涓哄己鏁堢殑浜 GRP40 婵€鍔ㄥ墏銆傝鑽鍚勭灞炲姩鐗╀篃琛ㄧ幇鍑鸿壇濂界殑鑽姩瀛︺€傚湪椋熻煿鐚翠綋鍐呯殑鍙ｆ湇鐢熺墿鍒╃敤搴︺€佹竻闄ょ巼鍜屽崐琛版湡鍒嗗埆涓 65%銆?.04 L/h/kg 鍜?4 灏忔椂銆傛澶栵紝澶ч紶鍙ｆ湇 5 mg/kg 鍚 3 灏忔椂鐨勮剳/琛€娴嗘瘮鍊间粎鏈 0.02锛岃瘉鏄庡ぇ鑴戠┛閫忓姏杈冧綆銆侫M-4468 瀵瑰績鑴 hERG 鍙椾綋鎴栬倽 CYP 閰剁殑娲绘€у井寮便€備汉 GPR40 鏁插叆灏忛紶涓紝钁¤悇绯栨縺鍙戝墠 4 灏忔椂鍙ｆ湇 10 mg/kg锛屾槑鏄鹃檷浣庝簡 AM-4468 娌荤枟灏忛紶鐨勮绯栨按骞筹紝姣旇祴褰㈠墏娌荤枟灏忛紶鐨勮憽钀勭硸鏇茬嚎涓嬮潰绉綆 19%銆傚彇鑷繖浜涘皬榧犵殑鑳拌吅鑳板矝缁嗚優涓紝鑽墿璇卞彂鑳板矝绱犲垎娉岀殑 EC50 涓 55 nM (Liu, J. et al ACS Med Chem Lett 2014, 5(5): 517)銆 GLP-1/2 鍙岄噸婵€鍔ㄥ墏 ZP-GG-72 鐨勯鎵规暟鎹嚭鐐 Zealand Pharma 鍏徃鐨 ZP-GG-72 鏄竴绉嶉珮琛€绯栫礌鏍疯偨 1锛圙LP-1锛?楂樿绯栫礌鏍疯偨 2锛圙LP-2锛夊彈浣撴縺鍔ㄥ墏锛屼唬璋㈡€у唴姣掔礌琛€鐥囩殑涓村簥鍓嶇爺绌朵腑璇佹槑鏈夋晥锛屾湁浜鸿涓轰唬璋㈡€у唴姣掔礌琛€鐥囦細闄嶄綆 2 鍨嬬硸灏跨梾鐨勮儼宀涚礌鏁忔劅鎬с€傝鑽浜 GLP-1 鍜 GLP-2 鍙椾綋鐨 EC50 鍊煎垎鍒负 0.33 鍜 0.65 nM銆備笌姝ょ浉姣旓紝鑹惧閭ｈ偨鍜屽埄鎷夐瞾鑲藉 GLP-1 鐨勫€煎垎鍒负 0.004 鍜 0.026 nM锛屾浛搴﹂瞾鑲藉 GLP-1 鍜 GLP-2 鐨勫€煎垎鍒负 50 鍜 0.05 nM銆傚皬榧犺嵂鍔ㄥ璇勪及鏄剧ず ZP-GG-72 鐨勫崐琛版湡涓 0.3 灏忔椂锛岃壘濉為偅鑲姐€佸埄鎷夐瞾鑲藉拰鏇垮害椴佽偨鍒嗗埆涓 1.1銆?.5 鍜 0.6 灏忔椂銆備互 250 鍜 500 mg/kg 姣忔棩鐨笅娉ㄥ皠 2 娆★紝ZP-GG-72 鏀瑰杽浜嗙槮寮卞皬榧犵殑琛€绯栨帶鍒讹紝澧炲姞浜嗗ぇ鑲犻噸閲忋€傝绯栨敼鍠勬簮鑷 GLP-1 鍙椾綋鐨勬縺鍔ㄤ綔鐢紝鑰岃偁閬撻噸閲忓鍔犲垯鏄 GLP-2 鍙椾綋鐨勬縺鍔ㄤ綔鐢ㄦ墍鑷淬€備笌姝ょ浉鍙嶇殑鏄紝鑹惧閭ｈ偨鍜屽埄鎷夐瞾鑲藉澶ц偁閲嶉噺鍗存病鏈夎繖浜涗綔鐢紝鏇垮害椴佽偨瀵硅绯栨帶鍒剁殑娲绘€ч檷浣庛€傞ギ椋熻鍙戣偉鑳栧皬榧犵殑鐮旂┒鏄剧ず鐩镐技鐨勬晥搴旂被鍨嬶紝浣 ZP-GG-72 鐨勫崐琛版湡寤堕暱鍒 8.8 灏忔椂銆俍P-GG-72 鏄綋鍓嶇殑涓村簥 GLP-1/GLP-2 鍗忓悓婵€鍔ㄥ€欓€夎嵂锛屽疁姣忔棩鐢ㄨ嵂涓€娆★紝瀵硅繖涓€灏氭湭婊¤冻鐨勪复搴婇渶姹傦紝鏈夋湜鎴愪负涓€涓柊鐨勬不鐤楁柟寮忥紙Russell, W.S. et al.74th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 13-17, San Francisco) 2014, Abst 374-OR锛夈€ FDA 鎵瑰噯 OMIDRIA 鐢ㄤ簬鐧藉唴闅滃拰鐪煎唴鏅朵綋缃崲鎵嬫湳 FDA 宸茬粡鎵瑰噯浜 Omeros 鍏徃鐨 Omidria(TM) 锛圤MS-302锛涢叜鍜吀姘ㄤ竵涓夐唶/鍘绘哀鑲句笂鑵猴級锛屼緵鐧藉唴闅滄垨鐪煎唴鏅朵綋缃崲锛坕ntraocular lens replacement锛孖LR锛夋湡闂翠娇鐢紝閫氳繃闃叉鏈棿鐬冲瓟缂╁皬鍜屽噺杞绘湳鍚庣柤鐥涳紝浠ヤ繚鎸佺灣瀛斿ぇ灏忋€傚嚭鑷鍏徃 PharmacoSurgery(R) 骞冲彴鐨勯娆惧晢涓氫骇鍝侊紝鏄墿鐬宠嵂鍜屾姉鐐庤嵂鐗╃殑涓撳埄澶嶆柟鑽紝涓虹櫧鍐呴殰鍜屽叾浠 ILR 鎵嬫湳鏈熼棿鏍囧噯浣跨敤鐨勫啿娲楁恫鍐嶆坊涓€鍛樸€傚湪鍏抽敭鎬ц瘯楠屼腑锛屾墍鏈夋偅鑰呭湪鏈墠閮戒娇鐢ㄦ爣鍑嗘墿鐬宠嵂鍜岄夯閱夎嵂锛孫midria 涓庡畨鎱板墏鐩告瘮锛屽棰勯槻鐬冲瓟缂╁皬鍙婂噺杞绘湳鍚庣柤鐥涚殑鏀瑰杽鍏锋湁缁熻瀛﹀拰涓村簥鎰忎箟锛?012 骞 3 鏈 14 鏃ュ拰 2012 骞 11 鏈 7 鏃ャ€婃堡妫矾閫忚嵂鐗╂柊闂汇€嬶級銆璇ュ叕鍙歌鍒掑鏈?绉嬪垵鍦ㄧ編鍥藉彂甯冧骇鍝侊紝鍑嗗宸ヤ綔鎺ヨ繎灏惧０锛圤meros News 鏂伴椈绋匡級銆 XOMA 鎺ㄥ嚭娌荤枟澧炵敓鎬х幓鐠冧綋瑙嗙綉鑶滅梾鐨勬柊鍨嬫姉 TGF-螔 MAB XOMA-089 鐢 XOMA 鍏徃鐮斿埗锛屽睘浜庝竴绉嶆柊鍨嬬殑瀹屽叏浜轰綋鍗曞厠闅嗘姉浣擄紝鍙腑鍜岃浆鍖栫敓闀垮洜瀛 (TGF) 尾-1 鍜尾-2 閰嶄綋锛屾嫙鐢ㄤ簬娌荤枟澧炵敓鎬х幓鐠冧綋瑙嗙綉鑶滅梾锛圥VR锛夛紝涓村簥鍓嶇爺绌惰瘎浠蜂簡鍏舵椿鎬с€傜粰甯︽湁璇卞彂 PVR 鐨勬湁鑹插鍏旂幓鐠冧綋鍐呮敞灏 XOMA-089锛屼互鏃堕棿鍜屽墏閲忎緷璧栨柟寮忛檷浣庝簡 PVR 鐨勪复搴婂垎绾у拰涓ラ噸绋嬪害锛屽寘鎷缃戣啘鑴辩鐨勪弗閲嶇▼搴﹀拰鐪煎唴鑶滅殑褰㈡垚銆傜 28 澶╋紝XOMA-089锛? mg/鐜荤拑浣擄級娉ㄥ皠浣 PVR 鍒嗙骇闄嶄綆 64.3%銆俋OMA-089 鍑忚交浜嗘偅鐪肩殑涓ラ噸绋嬪害锛屽悇椤硅瘯楠屼腑鍧囧垎浠 4.5 闄嶅埌 2.0锛屼粠 3.25 闄嶅埌 1.25銆傚湪鐩稿悓鍓傞噺姘村钩锛屽彂鐜板崟娆℃敞灏 XOMA-089 鎶戝埗 PVR 涓庢瘡鍛ㄦ敞灏勪竴娆 XOMA-089 鍚屾牱鏈夋晥銆俋OMA-089 娌荤枟鍑忚交浜嗚缃戣啘鑵旈殭鍐呯殑绾ょ淮鍖栥€侀€€鍖栧拰鍓ョ銆傚鍏旂幓鐠冧綋娑蹭腑锛孹OMA-089 鐨勭粓鏈祿搴︿娇鏆撮湶姘村钩闀夸箙淇濇寔锛涜€屽湪澶栧懆琛€涓紝XOMA-089 鐨勫嘲娴撳害寤惰繜鍑虹幇锛屽苟涓旀槑鏄句綆浜庡叾浠栫溂鐫涳紙Mirza, A. et al. 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ITMN-14440 鐨勪汉浣撲及璁℃湁鏁 AUC 鎻愮ず锛屼互鍚￠潪灏奸叜鍗佸垎涔嬩竴鐨勫墏閲忎究鍙彇寰楃浉褰撶殑娲绘€ф按骞筹紝鑰岃儍鑲犻亾鍓綔鐢ㄥ井涔庡叾寰紝鍏夋瘨鎬у拰闈炰复搴婅嵂鍔ㄥ鎻愮ず浜轰綋鍙瘡鏃ヤ竴娆℃垨姣忔棩涓ゆ鐢ㄨ嵂銆傚惎鍔 IND 鐨勫紑鍙戞椿鎬ф鍦ㄨ繘琛屼箣涓 (Ramphal, J. et al Int Conf Am Thorac Soc (May 16-21, San Diego) 2014, Abst A1953)銆 </p> </div> <div id="copy">浣滆€咃細涓嶈銆€鏉ユ簮锛氬箍宸炲尰鑽爺绌舵€婚櫌鏈夐檺鍏徃</div> <div class="sxart"> <li>涓婁竴绡囷細<a href="List.asp?ID=1301">鍥炵湼2012骞磋幏鎵筎op20鐣呴攢鑽璋佹槸鐜嬭€匋/a></li><li>涓嬩竴绡囷細<a href="List.asp?ID=1308">姣忔湀鑽墿蹇 -2014骞?鏈圏/a></li> </div> </div> <div id="web2l"> <h6>鐩稿叧鏂囩珷</h6> <div id="marticle"> <ul> <li>路<a href="/List.asp?ID=339">鑱旂郴鎴戜滑</a></li> <li>路<a href="/List.asp?ID=284">鑽墿闈炰复搴婅瘎浠风爺绌朵腑蹇傸br>锛堝浗瀹跺箍宸炴柊鑽畨鍏ㄨ瘎浠风爺绌堕噸鐐瑰疄楠屽锛堻/a></li> <li>路<a href="/List.asp?ID=274">骞胯嵂鎬婚櫌鏈夐檺鍏徃鐜颁换棰嗗</a></li> <li>路<a href="/List.asp?ID=1">骞胯嵂鎬婚櫌鏈夐檺鍏徃绠€浠婞/a></li> <li>路<a href="/List.asp?ID=285">鑽墿鍒跺墏鐮旂┒寮€鍙戜腑蹇傸br>锛堝箍宸炲競鎺ч噴鍒跺墏鐮旂┒寮€鍙戜腑蹇冿級</a></li> <li>路<a href="/List.asp?ID=271">骞胯嵂鎬婚櫌绠＄悊鏋舵瀯</a></li> <li>路<a 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